Contemporary Perspectives in Schizophrenia Care
Patient-Centric Care

Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program

Kane JM, et al.  Am J Psychiatry. 2016;173(4):362-372.
4 min

The Study

This report presents 2-year outcomes data from 404 first-episode psychosis (FEP) patients; 223 patients were assigned to comprehensive, multidisciplinary, team-based treatment (NAVIGATE), and 181 patients received usual community care. The NAVIGATE treatment model included 4 core interventions: personalized medication management, family psychoeducation, resilience-focused individual therapy, and supported employment/education.

The Analysis

The 223 NAVIGATE participants remained in treatment longer, experienced greater improvement in QoL and PANSS scores, and demonstrated more involvement with work and/or school than the 181 participants in standard community care. Notably, NAVIGATE participants with duration of untreated psychosis (DUP) <74 weeks, the median duration for the study, had greater improvement in QoL and psychopathology vs patients with longer DUP.

The Reason It Matters

This robust analysis from the RAISE program demonstrates that clinics across the country may be able to implement team-based intervention models for FEP in order to yield greater improvement in clinical and functional outcomes. The need to extend these models beyond FEP patients to preserve and consolidate functional improvements over the long term remains an area of ongoing investigation.

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