The cascading consequences of relapse can be overwhelming and interconnected1

The consequences of relapse on quality of life are stunningly pervasive in their reach.
This is because these consequences are not just multifactorial, but interconnected—so when one aspect of quality of life (QoL) declines, several others do too.1-4


Relationships Motivation Work Role Ownership Engagement inActivities Satisfaction Basic Needs Employment IndependentLiving GLOBAL FUNCTION GLOBALQoL SCORE QoL1 MEDICAL OUTCOMES Arrests Violence VICTIMIZATION MENTAL COMPONENT PHYSICAL COMPONENT Select a QoL score by clicking on a yellow plus sign to see the data.
MENTAL COMPONENT PHYSICAL OUTCOMES QoL Score 0 20 40 60 80 100 Remitted Non-Remitted Time (Months) 0 12 24 36 MENTAL COMPONENT PHYSICAL OUTCOMES Time (Months) 0 20 40 60 80 100 Remitted Non-Remitted Global Assessment Functioning Score 0 12 24 36 Percentage of Patients 0 3 6 9 12 15 Non-Remitted Remitted Time (Months) 0 12 24 36 SF-12 Score 35 40 45 50 55 Remitted Non-Remitted 0 12 24 36 Time (Months) SF-12 Score 35 40 45 50 55 Remitted Non-Remitted 0 12 24 36 Time (Months)

Failure to achieve symptom remission is associated with a web of worsening QoL and functioning scores3

A growing body of data all points to the same conclusion: Relapsing individuals experience deterioration and lack of improvement over time in nearly all domains of quality of life compared with individuals who are remitted, both cross-sectionally and longitudinally.1-4

Psychotic relapse triggers a cascade of clinical and psychosocial deterioration that can erode many aspects of patients’ personal and professional lives.1-4


As the risk of relapse decreases, symptom, functioning, and QoL scores improve.5 Relapse5 RemissionRecovery5 QoL5 Select a QoL score by clicking on a yellow plus sign to see the data.
Favors TAU Favors EIS 0.5 1.0 1.5 Risk Ratio (95% CI) P =.007 | Remission P =.02 | Recovery Favors TAU Favors EIS -0.5 0 0.5 Standardized Mean Difference (95% CI) P =.001 | Global Functioning P =.046 | Quality of Life Favors EIS Favors TAU 0.5 1.0 1.5 Risk Ratio (95% CI) RELAPSE | P =.01

Early intervention services improve many facets of a patient’s life5

Schizophrenia is one of the top 10 most debilitating disorders in the US, characterized by cycles of relapse and remission. But new research holds the promise of better outcomes through early intervention services (EIS) that are specifically designed to meet the recovery needs and goals of patients with schizophrenia. Compared to treatment as usual, EIS offers improved clinical outcomes, enabling a host of downstream improvements in personal and professional recovery as well as enhanced global functioning and quality of life.5

Counteracting the insidious web of consequences related to psychotic relapse requires a comprehensive approach. EIS offers the hope for a fundamental shift toward global recovery for patients with schizophrenia.5

Teva is committed to providing education and enhancing care for everyone living with schizophrenia.

The SCZ Now initiative was created to help support this educational effort.